Montmorillonite for pharmaceuticals is a kind of powder made from natural bentonite. It has water absorption, suspension, dispersion, cohesiveness and thixotropy. Montmorillonite for pharmaceuticals can be excellent pharmaceutical excipients with its function of emulsifying, thickening, suspending and adsorbing.
The lamellar structure and nonuniform charge distribution of montmorillonite particles have a strong fixation and inhibition on the viruses, pathogens, and the toxins, gases they produce in digestive tract.
In addition, the advantages of montmorillonite preparation are quite prominent, which includes rapid antidiarrheal, safety and no side effect. After entering the human digestive tract, it cannot be absorbed by the human body, or enter the blood circulation, and does not affect the gastrointestinal peristalsis and food digestion and absorption and in the main time greatly reduces the harmof diarrheato the body of the patients without any side effects. It is widely used in the field of treatment of children's diarrhea.
Product Parameters
Montmorillonite content: 99%
Expansion capacity: 19~44ml/g
Expansion rate: >12.5 mg/g
Particle size: 1.9~2.3 mu m
PH: 7~8
Dry weightlessness: <7%
Adsorption force: 1g / 0.39g (sulfuric acid)
Lead content: <2 ppm arsenic salt content: <2 ppm
Other: CaOH was no white precipitate, no chlorine ion
Chemical Composition
SiO2：55%
A12O3：16.54%
MgO：5.14%
CaO：3.97%
P2O5：2.15%
Na2O：1.18%
K2O：0.72%
Fe2O3：0.21%
TiO2：0.02%
MnO：0.007%
1. Adsorption / Immobilization
The inhomogeneous charge of montmorillonite can make it adsorb all kinds of digestive tract pathogenic factors and toxins.
2. Mucosal Barrier Function
Electrostatic binding of montmorillonite and digestive tract mucincan increase the amount of mucus and improve the mass of mucus to increase the cohesiveness and elasticity of the mucus.
3. Repair Effect
Montmorillonite can repair damaged digestive tract epithelial cells.
4. Coagulation
Montmorillonite can activate coagulation factors, and form the blood clot as the core of montmorillonite on the surface of digestive tract. It can also promote vasoconstriction and slow down local blood flow and reduce bleeding.
Other Uses of Montmorillonite for Pharmaceuticals
1. Suspending Agent
Suspensions have good bioavailability, and it has better for drug administration, especially for children and elderly people who have difficulty swallowing, it is convenient to take medicine. Montmorillonite is one of excellentsuspension agents in suspension.
2. Filtering Agent
In the production of drugs, montmorillonite can play the role of adsorbents and filters.
3. Emulsifier and Ointment Matrix
The montmorillonite can be used as a thickener for ointment and paste or as an emulsifier directly used in ointment matrix and emulsion. When being used in ointment matrix,the montmorillonite can avoid the stimulationof degenerative cream fat made from animal oil, vegetable oil and mineral oil. The property of montmorillonite is stable; it has no rancidity or deterioration, and can keep the inherent efficacy of the drug.
4. Binder
Montmorillonite has a certain viscosity; it can be applied in dental field, like dental cements, thickener and dentifrice toothpaste for treating oral diseases.
5. Carrier
Montmorillonite is a mineral with a nanoscale structure, in chemical synthesis, it can act as a catalyst carrier. It can also be used as a carrier of pesticides (insecticides and fungicides) to make the pesticide highly dispersed.
6. Excipient
Montmorillonite can be used as a medicinal excipient for its superior disintegration performance. It has no influence on the nervous, respiratory and cardiovascular systems. In some situations, the effect of montmorillonite as disintegrating agent is better than that of other disintegrating agents.
7. Antidote
Montmorillonite has the effect of detoxification on drugs like morphine, cocaine, taro alkali and alkali.